Publications

Explore our research at the Drug Discovery Lab

Selected Publications

  1. Campagna J, Jagodzinska B, Wi D, Zhu C, Lee J, Cohn W, Jun M, Elias C, Padder S, Descamps O, Peters-Libeu C, Zhang Q, Gorostiza O, Poksay K, Spilman P, Bredesen D, John V. Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. Neurotherapeutics, 2025, e00610, https://doi.org/10.1016/j.neurot.2025.e00610.
  2. Campagna J, Chandra S, Teter B, Cohn W, Pham J, Kim YS, Jagodzinska B, Vadivel K, Alam P, Bilousova T, Young M, Elias C, Marcucci J, Flacau I, Jackman A, Padder S, Wi D, Zhu C, Spilman P, Jung ME, Bredesen DE, John V. Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease. Sci Rep. 2025 Apr 23;15(1):14028. doi: 10.1038/s41598-025-96131-2. PMID: 40269061; PMCID: PMC12019328.
  3. Okabe N, Wei X, Abumeri F, Batac J, Hovanesyan M, Dai W, Azarapetian S, Campagna J, Pilati N, Marasco A, Alvaro G, Gunthorpe MJ, Varghese J, Cramer SC, Mody I, Carmichael ST. Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug. Nat Commun. 2025 Mar 15;16(1):2556. doi: 10.1038/s41467-025-57860-0. PMID: 40089466; PMCID: PMC11910580.
  4. Cohn W, Campagna J, Wi D, Lee JT, Beniwal S, Elezi G, Zhu C, Jagodzinska B, Whitelegge J, Damoiseaux R, John V. Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer's disease mice. NPJ Drug Discov. 2025;2(1):7. doi: 10.1038/s44386-025-00009-2. Epub 2025 May 2. PMID: 40322539; PMCID: PMC12048343.
  5. Wei X, Campagna JJ, Jagodzinska B, Wi D, Cohn W, Lee JT, Zhu C, Huang CS, Molnár L, Houser CR, John V, Mody I. A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2400420121. doi: 10.1073/pnas.2400420121. Epub 2024 Aug 6. PMID: 39106304; PMCID: PMC11331084.
  6. Campagna J, Jagodzinska B, Alvarez P, Yeun C, Enquist K, Cohn W, Fajtová P, O’Donoghue A, Arumugaswami V,Li M, Damoiseaux R, John V. Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an Mpro Protease Inhibitor for Treatment of SARS-CoV-2. Archives of Clinical and Biomedical Research 6 (2022): 993-1002. DOI: 10.26502/acbr.50170312.
  7. Okawa H, Kondo T, Hokugo A, Cherian P, Sundberg O, Campagna JJ, Kashemirov BA, John V, Sun S, Ebetino FH, McKenna CE, Nishimura I. Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice. Commun Med (Lond). 2022 Sep 5;2:112. doi: 10.1038/s43856-022-00172-x. PMID: 36082175; PMCID: PMC9445170.
  8. Okawa H, Kondo T, Hokugo A, Cherian P, Campagna JJ, Lentini NA, Sung EC, Chiang S, Lin YL, Ebetino FH, John V, Sun S, McKenna CE, Nishimura I. Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate. Elife. 2022 Aug 26;11:e76207. doi: 10.7554/eLife.76207. PMID: 36017995; PMCID: PMC9489207.
  9. Cohn W, Zhu C, Campagna J, Bilousova T, Spilman P, Teter B, Li F, Guo R, Elashoff D, Cole GM, Avidan A, Faull KF, Whitelegge J, Wong DTW, John V. Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue. Int J Mol Sci. 2022 May 9;23(9):5257.
  10. Okawa H, Kondo T, Hokugo A, Cherian P, Campagna J, Lentini N, Sun S, Sung E, Chiang S, Lin Y, Ebetino F, John V, McKenna C, Nishimura I. Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using equilibrium competing inert hydroxymethylene diphosphonate. 2021 10.1101/2021.12.22.21268006.
  11. Miyoshi E, Bilousova T, Melnik M, Fakhrutdinov D, Poon WW, Vinters HV, Miller CA, Corrada M, Kawas C, Bohannan R, Caraway C, Elias C, Maina KN, Campagna JJ, John V, Gylys KH. Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta. Lab Invest. 2021 Dec;101(12):1605-1617.
  12. Zhu C, Bilousova T, Focht S, Jun M, Elias CJ, Melnik M, Chandra S, Campagna J, Cohn W, Hatami A, Spilman P, Gylys KH, John V. Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model. Mol Brain. 2021 Apr 19;14(1):70
  13. Shu C, Parfenova L, Mokhonova E, Collado JR, Damoiseaux R, Campagna J, John V, Crosbie RH. High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy. Skelet Muscle. 2020 Sep 18;10(1):26.
  14. Liu J, Campagna J, John V, Damoiseaux R, Mokhonova E, Becerra D, Meng H, McNally EM, Pyle AD, Kramerova I, Spencer MJ. A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy. Cell Rep Med. 2020 Oct 20;1(7):100122
  15. Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ACS Chem Biol. 2020 Jun 19;15(6):1671-1684.
  16. Alexander Tuan-Huy Duong a, Bryan J. Simmons b, Mohammad Parvez Alam a, 2, Jesus Campagna a, Neil K. Garg b, 1, Varghese John. Synthesis of Fused Indolines by Interrupted Fischer Indolization in a Microfluidic Reactor. Tetrahedron Letters (2018).
  17. Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D, John V. (2018). A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. ACS Chem. Neurosci. 9 (3), 462-8.
  18. Jesus Campagna, Patricia Spilman, Barbara Jagodzinska, Dongsheng Bai, Asa Hatami, Chunni Zhu, Tina Bilousova, Michael Jun, Chris Jean Elias, Johnny Pham, Gregory Cole, Mary Jo LaDu, Michael E. Jung, Dale E. Bredesen, and Varghese John. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018; 8: 17574
  19. Bilousova, T., Elias, C., Miyoshi, E., Alam, M.P., Zhu, C., Campagna, J., Vadivel, K. Jagodzinska, B., Gylys, K., John, V. (2018). Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem Biophys Res Commun. 2018 May 23;499(4):751-757
  20. Campagna, J.; Vadivel, K. Jagodznska, B.; Jun, M.; Bilousova, T.; Spilman, P.;  John, V. (2018). Evaluation of an Allosteric Inhibitor Peptide to identify mimetics that can interact with the Loop F region of BACE and prevent APP cleavage. J Mol Biol. 2018 Apr 10
  21. Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.
  22. Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V. Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. Drug Deliv. 2017;2017:4759839
  23. Poksay KS, Sheffler DJ, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017 Feb 15;8:46
  24. Heinzelman P, Bilousova T, Campagna J, John V. Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy. Int J Alzheimers Dis. 2016;2016:8053139
  25. Alam MP, Jagodzinska B, Campagna J, Spilman P, John V. C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides. Tetrahedron Lett. 2016 May 11;57(19):2059-2062.
  26. Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 Mar 8;52(1):223-42
  27. Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. sAβPPα is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis. 2015;47(3):545-55
  28. Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014 Mar 10;1551:25-44
  29. Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, CAMPAGNA J, Jagodzinska B, Bredesen DE, John V. AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. J Alzheimers Dis. 2013;37(2):343-55